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Jan. 21, 2026

EP 170: Patient Capital in the Age of the $10B Seed | Brian Smith, S3 Ventures

The current venture market is defined by a dangerous decoupling of capital from reality. While the industry chases $10B seed valuations and trillion-dollar infrastructure bets, Brian Smith and S3 Ventures are executing a "Discipline Arbitrage." They argue that the real returns in AI will not come from the massive CapEx spenders, but from the application layer that solves boring, regulated, enterprise problems.

This episode audits the structural risks of the current AI wave …

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Jan. 21, 2026

Patient Capital in the Age of the $10B Seed | Brian Smith, S3 Ventures

The current venture market is defined by a dangerous decoupling of capital from reality. While the industry chases $10B seed valuations and trillion-dollar infrastructure bets, Brian Smith and S3 Ventures are executing a "Dis...

Listen to the Episode

Jan. 14, 2026

Ep 169: The Semiconductor Moment for the Mind

The market is mispricing the human brain. Some Investors view Brain-Computer Interfaces (BCI) and other neurotech as the next iteration of the medical device, a slightly better stent or a more advanced catheter. This is a category error. As Matt Angle (Paradromics) and Connor Glass (Phantom Neuro) articulate its not a product, its the next modem.

The parallel is the internet in 1993. We are moving from a low-bandwidth, text-based era of biology into a streaming, high-fidelity era. Th…

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Jan. 14, 2026

The Semiconductor Moment for the Mind

The market is mispricing the human brain. Some Investors view Brain-Computer Interfaces (BCI) and other neurotech as the next iteration of the medical device, a slightly better stent or a more advanced catheter. This is a cat...

Listen to the Episode

Dec. 12, 2025

Robot Punching is Easy, Standing is Hard

A clip from our episode "Combat as the Minimum Viable Product | Cix Liv, REK"

#robotics #RealSteel #UFC #FutureOfSports #MMA #Tech #AustinNext #CombatSports #HardTech

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Dec. 11, 2025

Robot Sports Before Laundry and Soldiers

A clip from our episode "Combat as the Minimum Viable Product | Cix Liv, REK"

#robotics #RealSteel #UFC #FutureOfSports #MMA #Tech #AustinNext #CombatSports #HardTech

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Dec. 10, 2025

Robot Title Match: Little Girl vs Navy Seal

A clip from our episode "Combat as the Minimum Viable Product | Cix Liv, REK"

#robotics #RealSteel #UFC #FutureOfSports #MMA #Tech #AustinNext #CombatSports #HardTech

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About the Host

Jason Scharf Profile Photo
Jason Scharf

Founder & Host

Jason Scharf has spent nearly two decades pursuing his life’s mission of catalyzing innovation. As an early stage investor, he targets the bio innovation tech stack and the business of health. He has held key leadership roles in strategy and market intelligence at industry pillars such as Illumina, BD, and Amgen. Through the Austin Next podcast and Substack Ecosystem Metacognition, he explores innovation, Bio & Health, tech, ecosystems, Austin, and their convergence.